''the nuclear lamina, which lies just inside the inner nuclear membrane, is a complex meshwork of multiple proteins, including the type v intermediate filament lamins a, c, b1 and b2. the nuclear lamina has roles not only in the maintenance of nuclear shape and structure, but also in transcriptional regulation, nuclear pore positioning and function, and heterochromatin organization. these non-structural functions are thought to be mediated through the direct binding of the lamina to both chromatin and a range of nuclear envelope proteins and transcription factors.''
brian c. capell and francis s. collins , nature reviews 2006
14 Mart 2013 Perşembe
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